Arterial spin labeling MRI to measure peak-exercise calf muscle perfusion reproducibly discriminates peripheral arterial disease from normal
نویسندگان
چکیده
Background Prior work demonstrated the utility of first-pass gadolinium-enhanced calf muscle perfusion MRI in patients with peripheral arterial disease (PAD). However patients with PAD often have advanced renal disease which prohibits the use of gadolinium-based contrast agents due to the concern for nephrogenic systemic fibrosis. ASL for quantification of calf muscle blood flow could provide a non-contrast alternative in advanced renal disease.
منابع مشابه
ASL demonstrates higher and more homogenous calf muscle perfusion with post-occlusion hyperemia than with exercise
Background Pulsed arterial spin labeling (PASL) is a non-contrast MRI technique capable of quantifying calf muscle perfusion with comparable accuracy to contrast enhancedMRI perfusion in normal subjects and peripheral arterial disease (PAD) patients. Peak perfusion can be achieved with exercise or during post-occlusion hyperemia. However, exercise stress may underestimate peak perfusion because...
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